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anti-TIE-2 antibody product blog

Posted on 2015-12-10 09:23:11 by mybiosource_staff
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Tags: Antibody; Monoclonal Antibody; TIE-2; anti-TIE-2 antibody; TIE-2, FITC-conjugated;
The TIE-2 tek (Catalog #MBS690466) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human TIE-2-FITC reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s TIE-2, FITC-conjugated can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS).
FACS: The suggested use of the antibody is <= 0.5 ug in 100 ul volume. It is recommended that the conjugate should be titrated for optimal performance for each application. Researchers should empirically determine the suitability of the TIE-2 tek for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The TIE-2 tek product has the following accession number(s) (GI #88758596) (NCBI Accession #NP_000450.2) (Uniprot Accession #Q02763). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Mouse Anti-Human TIE-2-FITC with the following immunoassay(s):
Testing Data
Testing Data TIE-2.

Tie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2. Human Tie-2 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18 residue putative signal peptide, a 727 residue extracellular domain and a 354 residue cytoplasmic domain. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse)/-4 (human). Ang-2 has been reported to act as an antagonist for Ang-1. Mice engineered to overexpress Ang-2 or to lack Ang-1 or Tie-2 display similar angiogenesis defects.

Immunogen: recombinant human soluble TIE-2
Conjugation: FITC
Preparation: Monoclonal antibodies were produced with the help of BALB/c mice using recombinant human soluble extracellular domain of TIE-2. Buffer/Stabilizer: PBS; 1% BSA
Preservative: 0,02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TIE-2 are readily searchable from our website. Different antibodies against the same target such as TIE-2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Bladder, Brain, Connective Tissue, Embryonic Tissue, Eye, Kidney, Lung, Muscle, Uterus, Vascular tissues are correlated with this protein. TIE-2 also interacts with the following gene(s): ANGPT1, ANGPT2, ANGPT4, DOK2, GRB2, GRB7, PTPN11, SHC1. The following patways have been known to be associated with this gene. Cardiovascular Diseases, Heart Diseases, Inflammation, Liver Diseases, Lung Neoplasms, Necrosis, Neoplasms, Neoplasms, Experimental, Neovascularization, Pathologic, Nervous System Diseases are some of the diseases may be linked to Mouse Anti-Human TIE-2-FITC.
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