|The Tip60 kat5 (Catalog #MBS476865) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Tip60 Mouse mAb reacts with Human, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Tip60 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the Tip60 kat5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Tip60 kat5 product has the following accession number(s) (GI #332205931) (NCBI Accession #NP_001193762.1) (Uniprot Accession #Q92993). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-Tip60 Mouse mAb with the following immunoassay(s):
Western Blot (WB) (Western blot detection of Tip60 in MCF7, C6 and Hela cell lysates using Tip60 mouse mAb (1:2000 diluted).Predicted band size:60KDa.Observed band size:60KDa.)
Entrez Summary: The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.
UniPort Summary Function: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565).
Immunogen: Purified recombinant fragment of human TIP60 (AA: 18-208) expressed in E Coli.
Sequence Similarities: Contains 1 MYST-type HAT (histone acetyltransferase) domain.