Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
Fax 1.858.633.0166    Email 
menu1 Home Products Ordering Company Help menu7
   MyBioSource  rightarrow Monoclonal Antibody Blog  rightarrow anti-TLR2 antibody  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Blogs moreseparator
 • anti-CYP2J2 antibody blog
 • anti-S100A8 antibody blog
 • anti-CREB-1 antibody blog
 • anti-CRYAB antibody blog
 • anti-CLASP2 antibody blog
 • anti-KIAA1967 antibody blog
 • anti-Influenza A, Avian, H5N1, Hemagglutinin (HA) (Bird Flu) antibody blog
 • anti-IgG antibody blog
 • anti-Slc38a1 antibody blog
 • anti-CD37 antibody blog
 • anti-RBBP8 antibody blog
 • anti-PANX2 antibody blog
 • anti-TNFSF1A antibody blog
 • anti-S100A6 antibody blog
 • anti-CA9 antibody blog
 • anti-POLE2 antibody blog
 • anti-Hcn2 antibody blog
 • anti-CEA antibody blog
 • anti-SERPINB2 antibody blog
 • anti-hHIV-1 antibody blog
Blog Categories separator
 • Assay Kit Blogs
 • Biochemical Blogs
 • cDNA Clone Blogs
 • Monoclonal Antibody Blogs
 • Polyclonal Antibody Blogs
 • Rec/Purified Protein Blogs
 • Popular Product Blogs
Our Best Sellers moreseparator
 • Disintegrin and metalloproteinase domain-containing protein ... Antibody
 • Cyclophilin D (CYPD) ELISA Kit
 • Gastrin Tetrapeptide Peptide
 • PPAR DELTA Antibody
 • Cathepsin S (CTSS) ELISA Kit
 • Hepcidin ELISA Kit
 • Cav-1 ELISA Kit
 • Salmonella O Antibody
 • LATS1-2 Antibody
 • E2 estradiol ELISA Kit
 • N-MID Osteocalcin (N-MID-OT) ELISA Kit
 • anti-Protein A (faeC) Antibody
 • RORgamma Antibody
 • Apolipoprotein A1 (APOA1) Antibody
 downarrow more ...

anti-TLR2 antibody product blog

Posted on 2017-05-15 19:27:02 by mybiosource_staff
Share it on ...     
Tags: Antibody; TLR2; Monoclonal Antibody; anti-TLR2 antibody;
The TLR2 tlr2 (Catalog #MBS584737) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TLR2, Human, mAb TL2.1, Functional Study Antibody, Low Endotoxin reacts with Human, Canine, Cynomolgus Monkey, Monkey, Rhesus Monkey and may cross-react with other species as described in the data sheet. MyBioSource\'s TLR2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Formalin/Paraffin, Flow Cytometry (FC/FACS), Functional Studies (FS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB).
Flow Cytometry: 2 ug antibody per 300000 cells; untreated as well as 0.4 % formaldehyde fixed cells can be used; do not permeabilize the cells or use 4 % faraformaldehyde as fixative!
The typical starting working dilution is 1:50. Researchers should empirically determine the suitability of the TLR2 tlr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The TLR2 tlr2 product has the following accession number(s) (GI #823672066) (NCBI Accession #AKI71244.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

The monoclonal antibody TL2.1 recognizes human Toll-like receptor 2 (TLR2, CD282). Toll-like receptors (TLR) are highly conserved throughout evolution and are involved in the innate defence to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defences. In mammals, TLRs are identified as type I transmembrane signaling receptors with pattern recognition capabilities. They have been implicated in the innate host defence to pathogens. TLR2 is expressed on macrophages, smooth muscle, lung, spleen, thymus, brain and adipose tissue.
TLR2 has been identified as a receptor that is central to the innate immune response to lipoproteins of Gram-negative bacteria, several whole Gram-positive bacteria, as well as a receptor for peptidoglycan and lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. TLR2 cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. It cooperates with TLR1 to mediate te innate immune response to bacterial lipoproteins or lipopeptides. It acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. TLR2 also promotes apoptosis in response to lipoproteins.
Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, S. aureus, B Burgdorferi, T pallidum, M fermentans and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2.
The monoclonal antibody TL2.1 is a TLR2 function blocking antibody that is useful for studies on the role of TLR2 as a pattern recognition receptor in microbial products induced cytokine production by TLR2 bearing cells such as human peripheral blood mononuclear cells.

TLR2 tlr2

horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions