anti-TNFRSF10D antibody product blog
Tags: Antibody; Monoclonal Antibody; TNFRSF10D; anti-TNFRSF10D antibody;
The TNFRSF10D tnfrsf10d (Catalog #MBS690317) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human TNFRSF10D reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s TNFRSF10D can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Flow Cytometry (FC/FACS), Neutr. Researchers should empirically determine the suitability of the TNFRSF10D tnfrsf10d for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The TNFRSF10D tnfrsf10d product has the following accession number(s) (GI #22547108) (NCBI Accession #NP_003831.2) (Uniprot Accession #Q9UBN6). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
TNF-related apoptosis-inducing ligand (TRAIL), also known as Apo-2 ligand and TNFSF10, is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members. TRAIL binds at least five different receptors: TRAIL R1 (DR4), R2 (DR5), R3 (DcR1), R4 (DcR2), and osteoprotegerin (OPG). TRAIL receptors all exhibit cysteine-rich repeats characteristic of the TNF receptor superfamily. TRAIL R1 and R2 are type 1 transmembrane proteins with intracellular death domains (DD) and, subsequently, have the ability to mediate TRAIL-induced apoptosis. The remaining receptors are decoys that may regulate TRAIL activity by competing for binding sites with TRAIL R1 and R2. TRAIL R3 is membrane-associated via GPI linkage. TRAIL R4 is a type 1 transmembrane receptor, but exhibits a truncated cytoplasmic domain. Like the active receptors TRAIL R1 and R2, OPG has a DD motif but is a soluble protein.
Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of TNFRSF10D extracellular domain (also called TRAIL R4). Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TNFRSF10D are readily searchable from our website. Different antibodies against the same target such as TNFRSF10D may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Brain, Kidney, Lung, Pancreas, Placenta, Prostate, Skin, Stomach, Testis, Vascular tissues are correlated with this protein.