|The TNFRSF11B tnfrsf11b (Catalog #MBS690623) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Rat Anti-Mouse TNFRSF11B reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s TNFRSF11B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the TNFRSF11B tnfrsf11b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TNFRSF11B tnfrsf11b product has the following accession number(s) (GI #113930716) (NCBI Accession #NP_032790.3) (Uniprot Accession #O08712). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Osteoprotegerin (OPG)/osteoclastogenesis inhibitory factor (OCIF) is a member of the TNF receptor superfamily and is now referred to as TNFRSF11B. It is an osteoblast secreted decoy receptor that binds specifically to osteoprotegrin ligand (OPGL/TNFSF11) to inhibit osteoblast maturation. It is also a decoy receptor for TRAIL and inhibits TRAIL-induced apoptosis. Human and mouse OPG share approximately 84% and 94% amino acid sequence identity, respectively, with rat OPG. Natural OPG exists predominantly as disulfide-linked dimers.
Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TNFRSF11B are readily searchable from our website. Different antibodies against the same target such as TNFRSF11B may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Brain, Embryonic Tissue, Heart, Inner Ear, Intestine, Kidney, Lung, Mammary Gland, Spinal Cord, Uterus tissues are correlated with this protein. The following patways have been known to be associated with this gene. Arthritis, Rheumatoid, Bone Resorption, Cardiovascular Diseases, Inflammation, Kidney Diseases, Necrosis, Neoplasms, Nervous System Diseases, Osteolysis, Osteoporosis are some of the diseases may be linked to Rat Anti-Mouse TNFRSF11B.