|The Tyk2 tyk2 (Catalog #MBS475709) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Tyk2 Mouse mAb reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Tyk2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the Tyk2 tyk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Tyk2 tyk2 product has the following accession number(s) (GI #958192451) (NCBI Accession #JAO13557.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-Tyk2 Mouse mAb with the following immunoassay(s):
Western Blot (WB) (Western blot analysis using TYK2 mouse mAb against truncated TYK2 recombinant protein (1) and Jurkat cell lysate (2).)
Entrez Summary: Tyk2 (tyrosine kinase 2), with 1187-amino acid protein (about 131kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.
Immunogen: Purified recombinant fragment of Tyk2 expressed in E Coli. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Tyk2 are readily searchable from our website. Different antibodies against the same target such as Tyk2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Tyk2 also interacts with the following gene(s): IFNAR1, PTPN1, SOCS1, SOCS3, STAT1, STAT2, STAT3, STAT5A, STAT5B, STAT6. The following patways have been known to be associated with this gene. Blood, Bone, Bone Marrow, Brain, Kidney, Liver, Lung, Muscle, Skin, Vascular tissues are correlated with this protein. Arthritis, Rheumatoid, Brain Diseases, Carcinoma, Hepatocellular, Cardiovascular Diseases, Inflammation, Liver Diseases, Multiple Sclerosis, Necrosis, Nervous System Diseases, Psoriasis are some of the diseases may be linked to Anti-Tyk2 Mouse mAb.