anti-USP5 antibody product blog
Tags: Antibody; Monoclonal Antibody; Usp5; anti-USP5 antibody;
The USP5 usp5 (Catalog #MBS9200562) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The USP5 Antibody reacts with Human, mouse, rat and may cross-react with other species as described in the data sheet. MyBioSource\'s USP5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA).WB~~1:2000. Researchers should empirically determine the suitability of the USP5 usp5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The USP5 usp5 product has the following accession number(s) (GI #148727331) (NCBI Accession #NP_001092006.1) (Uniprot Accession #P45974). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the USP5 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of lysates from U251, PC-3 cell line, mouse brain, rat brain and liver tissue lysates (from left to right), using USP5 Antibody. MBS9200562 was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L(HRP) at 1:3000 dilution was used as the secondary antibody. Lysates at 35ug per lane.)
Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored \'Lys-48\'-linked polyubiquitin disassembly. Binds linear and \'Lys- 63\'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Antigen Type: Recombinant Protein
Crown Antibody: Yes. Antigen Source: HUMAN. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing USP5 are readily searchable from our website. Different antibodies against the same target such as USP5 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Eye, Liver, Muscle, Nerve, Thyroid tissues are correlated with this protein. Carcinoma, Hepatocellular, Drug Hypersensitivity, Hyperplasia, Inflammation, Liver Diseases, Liver Neoplasms, Necrosis, Nervous System Diseases, Pain are some of the diseases may be linked to USP5 Antibody.