|The VEGFR-1/Flt-1 flt1 (Catalog #MBS690832) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human VEGFR-1/Flt-1 reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s VEGFR-1/Flt-1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP).
Western Blot: Use at 1-10 ug/ml ELISA: Use at 1-10 ug/ml Others For IP uuse at 1-5 ug/ml. Researchers should empirically determine the suitability of the VEGFR-1/Flt-1 flt1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The VEGFR-1/Flt-1 flt1 product has the following accession number(s) (GI #229892220) (NCBI Accession #NP_001153392) (Uniprot Accession #P17948). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Mouse Anti-Human VEGFR-1/Flt-1 with the following immunoassay(s):
Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes, dendritic cells and on trophoblast cells. The flt-1 gene was first described in 1990. The receptor contains seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular splited tyrosine kinase domain. Compared to VEGFR-2 the Flt-1 receptor has a higher affinity for VEGF but a weaker signaling activity. VEGFR-1 thus leads not to proliferation of endothelial cells, but mediates signals for differentiation. Interestingly a naturally occuring soluble variant of VEGFR-1 (sVEGFR-1) was found in HUVE supernatants in 1996, which is generated by alternative splicing of the flt-1 mRNA.
Immunogen: recombinant human soluble Flt-1 (D5) (RT# S01-012). Buffer: PBS. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing VEGFR-1/Flt-1 are readily searchable from our website. Different antibodies against the same target such as VEGFR-1/Flt-1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Adenocarcinoma, Brain Diseases, Heart Diseases, Hypertension, Inflammation, Necrosis, Neoplasms, Nervous System Diseases, Pre-Eclampsia, Proteinuria are some of the diseases may be linked to Mouse Anti-Human VEGFR-1/Flt-1.