anti-Verotoxin I-B subunit antibody product blog
Tags: Antibody; Monoclonal Antibody; Verotoxin I-B Subunit; anti-Verotoxin I-B Subunit antibody;
The Verotoxin I-B subunit n/a (Catalog #MBS608228) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Verotoxin I-B subunit can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in Western Blot, ELISA and Inhibition.
Dilution: Western Blot: 1:10
Inhibition: in vitro dilutions should be made according to the amount of toxin to be inactiviated. Researchers should empirically determine the suitability of the Verotoxin I-B subunit n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Verotoxins are also called Shiga-like toxins (SLTs). Enterohemorrhagic Escherichia coli (EHEC) strains which are primarily of serotypes 0157:H7, 026:H11 and O111:H8 have been incriminated as etiologic agents of hemorrhagic colitis and Hemolytic-uremic syndrome, a generalized disease characterized by acute renal failure, thrombocytopenia and microangiopathic hemolytic anemia. There are several distinct E.coli SLTs. SLT-I and SLT-II are produced by EHEC. SLT-I and Shiga toxin share > 99% deduced amino acid sequence homology, whereas SLT-I and SLT-II share about 60% deduced amino acid sequence homology. SLT-I and SLT-II are antigenically distinct. The protein structure of the toxin consists of two domains: the A polypeptide that inhibits protein synthesis by targeting ribosomes, and the B polypeptide pentamer that binds to the eukaryotic cell receptor globotriaosylceramide (Gb3) leading to receptor-mediated endocytosis.
In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Verotoxin I-B subunit are readily searchable from our website. Different antibodies against the same target such as Verotoxin I-B subunit may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.