|The vitronectin receptor (CD51) n/a (Catalog #MBS570190) is an Antibody produced from Mouse (Balb/c) and is intended for research purposes only. The product is available for immediate purchase. The Mouse anti Human vitronectin receptor (CD51) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s vitronectin receptor (CD51) can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Immunohistochemistry (IHC) (frozen), Immunoprecipitation (IP).
NKI-M9 is useful for ELISA, immunoprecipitation, flow cytometry and immunohistochemsitry on frozen sections. Optimal antibody dilution should be determined by titRation. Researchers should empirically determine the suitability of the vitronectin receptor (CD51) n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
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CD51 (Cluster of Differentiation 51), known as vitronectin receptor alpha chain, or integrin alphaV is a type I integral membrane glycoprotein. CD51 forms a heterodimer with integrin beta1 (CD29), beta3 (CD61), beta5, beta6, or beta8. CD51 contains two disulfide-linked subunits of 125 kD and 24 kD. Many extracellular matrix proteins with RGD-motifs are CD51 ligands. In association with its beta chains, CD51 binds vitronectin, von Willebrand factor, fibronectin, thrombospondin, osteopontin, fibrinogen, and laminin. CD51, as an adhesion molecule, plays important roles in leukocytes homing and rolling, mediates bone absorption and angiogenesis. CD51 is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells.
Source Note: NKI-M9 is a Mouse monoclonal IgG2a antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with cultured melanoma cells derived from a Human melanoma metastasis. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing vitronectin receptor (CD51) are readily searchable from our website. Different antibodies against the same target such as vitronectin receptor (CD51) may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.