anti-Wnt-8a antibody product blog
Tags: Antibody; Monoclonal Antibody; Wnt-8a; anti-Wnt-8a antibody;
The Wnt-8a wnt8a (Catalog #MBS690108) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Rat Anti-Mouse Wnt-8a reacts with Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s Wnt-8a can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the Wnt-8a wnt8a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The Wnt-8a wnt8a product has the following accession number(s) (GI #17505195) (NCBI Accession #NP_490645.1) (Uniprot Accession #Q9H1J5). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Wnt-8a is a secreted glycoprotein that binds to receptors of the Frizzled family. Wnt-8a is expressed during early optic lens development and cardiac myogenesis. The expression of Wnt-8a has also been shown to be upregulated during primitive hematopoiesis. TGF-beta has been shown to increase Wnt-8a secretion during epithelial mesenchymal transition (EMT). The Wnts make up a large family of secreted proteins with roles in pattern formation, cell fate decision, axon guidance, and tumor formation. Wnt family members vary in length between 350 and 400 amino acids (aa), possess 22 to 24 conserved cysteines, are highly hydrophobic, and show 20 - 85% aa identity within the Wnt family. In general, there are three signaling pathways associated with Wnt-receptor interaction. The first is commonly called the canonical pathway and ultimately culminates in beta-Catenin accumulation and TCF/LEF-1-mediated gene transcription. The other two less well-defined non-canonical pathways include the Wnt/Ca2+ pathway and the planar cell polarity (PCP) pathway.
Reconstitution: Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Wnt-8a are readily searchable from our website. Different antibodies against the same target such as Wnt-8a may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Abnormalities, Multiple, Craniofacial Abnormalities, Edema, Eye Abnormalities, Fibrosis, Hypertrophy, Microcephaly, Necrosis, Nervous System Malformations are some of the diseases may be linked to Rat Anti-Mouse Wnt-8a.