C4a blocking peptide product blog
Tags: C4A; Blocking Peptide; C4a blocking peptide;
The C4a c4a (Catalog #MBS542493) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s C4a can be used in a range of immunoassay formats including, but not limited to, Immunocompetition, Immunodepletion.Western Blot: 1:500. Researchers should empirically determine the suitability of the C4a c4a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The C4a c4a product has the following accession number(s) (GI #476007827) (NCBI Accession #P0C0L4.2) (Uniprot Accession #P0C0L4). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Antigenic Blocking Peptide Complement C4-A
Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
Immunogen: Synthetic peptide taken within amino acid region 1220-1270 on human complement C4-A preprotein.
Expression: Complement component C4 is expressed at highest levels in the liver, at moderate levels in the adrenal cortex, adrenal medulla, thyroid gland, and the kidney, and at lowest levels in the heart, ovary, small intestine, thymus, pancreas and spleen. The extra-hepatic sites of expression may be important for the local protection and inflammatory response. Molecular Function: Complement component C1q binding; Endopeptidase inhibitor activity
Structure: Contains 1 anaphylatoxin-like domain.
Contains 1 NTR domain.
Subcellular Location: Secreted. Brain Diseases, Disorders of Sex Development, Fibrosis, Heart Diseases, Hyperplasia, Inflammation, Kidney Diseases, Liver Diseases, Lupus Erythematosus, Systemic, Necrosis are some of the diseases may be linked to C4a Peptide. C4a also interacts with the following gene(s): C3AR1, C4A, C4BPA, C4BPB, CD46, CFI, CR1, MASP2. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Heart, Intestine, Kidney, Liver, Lung, Muscle, Spleen tissues are correlated with this protein.