anti-Ly108 antibody product blogThe Ly108 slamf6 (Catalog #MBS834446) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. MyBioSource\'s Ly108 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS).
FC: 0.5 ug/test
A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Researchers should empirically determine the suitability of the Ly108 slamf6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Ly108 slamf6 product has the following accession number(s) (GI #109287787) (NCBI Accession #BAE96314.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Ly108 antibody (PE) with the following immunoassay(s):
Flow Cytometry (Flow Cytometric analysis using Ly108 antibody
Staining of C57Bl/6 splenocytes with CD45R antibody (FITC) and 0.06 ug of Mouse IgG2a K Isotype Control (PE) (left) or 0.06 ug of Ly-108 antibody (PE) (right). Cells in the lymphocyte gate were used for analysis.)
Mouse monoclonal Ly108 antibody (PE).
Biological Significance: The 13G3-19D monoclonal antibody reacts with mouse Ly108, the mouse homologue of human SLAMF6. Mouse Ly108 is also known as NTB-A, and is expressed on NK, T cells, and B cells. Engagement of the Ly108 receptor enhances NK cell activity and expression of IFN-gamma, and contributes to the inability of NK cells to kill Epstein Barr virus-infected B cells in X-linked lymphoproliferative disease. CD4+ T cells from Ly108 knock-out mice exhibit diminished ability to produce IL-4 and defective neutrophil functions.Staining has not revealed any strain differences between C57BL/6 and BALB/c mice. Other strains have not been tested. Tag/Conjugate: PE. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Ly108 are readily searchable from our website. Different antibodies against the same target such as Ly108 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.