anti-ORAI1 antibody product blogThe ORAI1 orai1 (Catalog #MBS9400225) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The ORAI1 Monoclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s ORAI1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the ORAI1 orai1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The ORAI1 orai1 product has the following accession number(s) (GI #75771974) (NCBI Accession #AAI04634.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the ORAI1 Monoclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of ORAI1 in human spleen tissue lysate with ORAI1 antibody at (A) 1 and (B) 2 ug/mL.)
Immunohistochemistry (IHC) (Immunohistochemistry of ORAI1 in human spleen tissue with ORAI1 antibody at 2.5 ug/mL.)
Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one fo rm of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.
Immunogen Type: Peptide
Immunogen Description: Raised against a 16 amino acid peptide from near the carboxy terminus of human ORAI1. Target Name: ORAI1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing ORAI1 are readily searchable from our website. Different antibodies against the same target such as ORAI1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. ORAI1 also interacts with the following gene(s): ITPR1, ITPR3, STIM1, STIM2, TRPC1, TRPC3, TRPC4, UBQLN1. Blood, Bone, Bone Marrow, Brain, Heart, Kidney, Lung, Prostate, Salivary Gland, Skin tissues are correlated with this protein.